EEG-GCNN: Augmenting Electroencephalogram-based Neurological Disease Diagnosis using a Domain-guided Graph Convolutional Neural Network

Neeraj Wagh, Yogatheesan Varatharajah
Proceedings of the Machine Learning for Health NeurIPS Workshop, PMLR 136:367-378, 2020.

Abstract

This paper presents a novel graph convolutional neural network (GCNN)-based approach for improving the diagnosis of neurological diseases using scalp-electroencephalograms (EEGs). Although EEG is one of the main tests used for neurological-disease diagnosis, the sensitivity of EEG-based expert visual diagnosis remains at ∼50%. This indicates a clear need for advanced methodology to reduce the false negative rate in detecting abnormal scalp-EEGs. In that context, we focus on the problem of distinguishing the abnormal scalp EEGs of patients with neurological diseases, which were originally classified as ‘normal’ by experts, from the scalp EEGs of healthy individuals. The contributions of this paper are three-fold: 1) we present EEG-GCNN, a novel GCNN model for EEG data that captures both the spatial and functional connectivity between the scalp electrodes, 2) using EEG-GCNN, we perform the first large-scale evaluation of the aforementioned hypothesis, and 3) using two large scalp-EEG databases, we demonstrate that EEG-GCNN significantly outperforms the human baseline and classical machine learning (ML) baselines, with an AUC of 0.90.

Cite this Paper

BibTeX
@InProceedings{pmlr-v136-wagh20a, title = {EEG-GCNN: Augmenting Electroencephalogram-based Neurological Disease Diagnosis using a Domain-guided Graph Convolutional Neural Network}, author = {Wagh, Neeraj and Varatharajah, Yogatheesan}, booktitle = {Proceedings of the Machine Learning for Health NeurIPS Workshop}, pages = {367--378}, year = {2020}, editor = {Alsentzer, Emily and McDermott, Matthew B. A. and Falck, Fabian and Sarkar, Suproteem K. and Roy, Subhrajit and Hyland, Stephanie L.}, volume = {136}, series = {Proceedings of Machine Learning Research}, month = {11 Dec}, publisher = {PMLR}, pdf = {http://proceedings.mlr.press/v136/wagh20a/wagh20a.pdf}, url = {https://proceedings.mlr.press/v136/wagh20a.html}, abstract = {This paper presents a novel graph convolutional neural network (GCNN)-based approach for improving the diagnosis of neurological diseases using scalp-electroencephalograms (EEGs). Although EEG is one of the main tests used for neurological-disease diagnosis, the sensitivity of EEG-based expert visual diagnosis remains at ∼50%. This indicates a clear need for advanced methodology to reduce the false negative rate in detecting abnormal scalp-EEGs. In that context, we focus on the problem of distinguishing the abnormal scalp EEGs of patients with neurological diseases, which were originally classified as ‘normal’ by experts, from the scalp EEGs of healthy individuals. The contributions of this paper are three-fold: 1) we present EEG-GCNN, a novel GCNN model for EEG data that captures both the spatial and functional connectivity between the scalp electrodes, 2) using EEG-GCNN, we perform the first large-scale evaluation of the aforementioned hypothesis, and 3) using two large scalp-EEG databases, we demonstrate that EEG-GCNN significantly outperforms the human baseline and classical machine learning (ML) baselines, with an AUC of 0.90.} }
Endnote
%0 Conference Paper %T EEG-GCNN: Augmenting Electroencephalogram-based Neurological Disease Diagnosis using a Domain-guided Graph Convolutional Neural Network %A Neeraj Wagh %A Yogatheesan Varatharajah %B Proceedings of the Machine Learning for Health NeurIPS Workshop %C Proceedings of Machine Learning Research %D 2020 %E Emily Alsentzer %E Matthew B. A. McDermott %E Fabian Falck %E Suproteem K. Sarkar %E Subhrajit Roy %E Stephanie L. Hyland %F pmlr-v136-wagh20a %I PMLR %P 367--378 %U https://proceedings.mlr.press/v136/wagh20a.html %V 136 %X This paper presents a novel graph convolutional neural network (GCNN)-based approach for improving the diagnosis of neurological diseases using scalp-electroencephalograms (EEGs). Although EEG is one of the main tests used for neurological-disease diagnosis, the sensitivity of EEG-based expert visual diagnosis remains at ∼50%. This indicates a clear need for advanced methodology to reduce the false negative rate in detecting abnormal scalp-EEGs. In that context, we focus on the problem of distinguishing the abnormal scalp EEGs of patients with neurological diseases, which were originally classified as ‘normal’ by experts, from the scalp EEGs of healthy individuals. The contributions of this paper are three-fold: 1) we present EEG-GCNN, a novel GCNN model for EEG data that captures both the spatial and functional connectivity between the scalp electrodes, 2) using EEG-GCNN, we perform the first large-scale evaluation of the aforementioned hypothesis, and 3) using two large scalp-EEG databases, we demonstrate that EEG-GCNN significantly outperforms the human baseline and classical machine learning (ML) baselines, with an AUC of 0.90.
APA
Wagh, N. & Varatharajah, Y.. (2020). EEG-GCNN: Augmenting Electroencephalogram-based Neurological Disease Diagnosis using a Domain-guided Graph Convolutional Neural Network. Proceedings of the Machine Learning for Health NeurIPS Workshop, in Proceedings of Machine Learning Research 136:367-378 Available from https://proceedings.mlr.press/v136/wagh20a.html.

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