Stroke Lesion Outcome Prediction Based on 4D CT Perfusion Data Using Temporal Convolutional Networks

Kimberly Amador, Matthias Wilms, Anthony Winder, Jens Fiehler, Nils Forkert
Proceedings of the Fourth Conference on Medical Imaging with Deep Learning, PMLR 143:22-33, 2021.

Abstract

Acute ischemic stroke is caused by a blockage in the cerebral arteries, resulting in long-term disability and sometimes death. To determine the optimal treatment strategy, a patient-specific assessment is often based on advanced neuroimaging data, such as spatio-temporal (4D) CT Perfusion (CTP) imaging. To date, perfusion maps are typically calculated from 4D CTP data and then thresholded to localize and quantify the stroke lesion core and tissue-at-risk. A few studies have recently developed deep learning methods to predict stroke lesion outcomes from perfusion maps. The basic idea of these is to train a model, using perfusion maps acquired at baseline and their corresponding follow-up images acquired several days after treatment, to automatically estimate the final lesion location and volume in new patients. Nevertheless, model training based on the original 4D CTP scans might be desirable, as they could contain more valuable information not directly represented in perfusion maps. Therefore, we aimed to develop and evaluate a temporal convolutional neural network (TCN) to predict stroke lesion outcomes directly from 4D CTP datasets acquired at admission, without computing any perfusion maps. Using a total of 176 CTP scans, we investigated the impact of the time window size by training the proposed TCN on various numbers of CTP frames: 8, 16, and 32 time points. For comparison purposes, we also trained a convolutional neural network based on perfusion maps. The results show that the model trained on 32 time points yielded significantly higher Dice values (0.33$\pm$0.21) than the models trained on 8 time points (0.25$\pm$0.20; P$<$0.05), 16 time points (0.28$\pm$0.21; P$<$0.001), and perfusion maps (0.23$\pm$0.18; P$<$0.05). These experiments demonstrate that the proposed model effectively extracts spatio-temporal data from CTP scans to predict stroke lesion outcomes, which leads to better results than using perfusion maps.

Cite this Paper

BibTeX
@InProceedings{pmlr-v143-amador21a, title = {Stroke Lesion Outcome Prediction Based on 4D {CT} Perfusion Data Using Temporal Convolutional Networks}, author = {Amador, Kimberly and Wilms, Matthias and Winder, Anthony and Fiehler, Jens and Forkert, Nils}, booktitle = {Proceedings of the Fourth Conference on Medical Imaging with Deep Learning}, pages = {22--33}, year = {2021}, editor = {Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris}, volume = {143}, series = {Proceedings of Machine Learning Research}, month = {07--09 Jul}, publisher = {PMLR}, pdf = {https://proceedings.mlr.press/v143/amador21a/amador21a.pdf}, url = {https://proceedings.mlr.press/v143/amador21a.html}, abstract = {Acute ischemic stroke is caused by a blockage in the cerebral arteries, resulting in long-term disability and sometimes death. To determine the optimal treatment strategy, a patient-specific assessment is often based on advanced neuroimaging data, such as spatio-temporal (4D) CT Perfusion (CTP) imaging. To date, perfusion maps are typically calculated from 4D CTP data and then thresholded to localize and quantify the stroke lesion core and tissue-at-risk. A few studies have recently developed deep learning methods to predict stroke lesion outcomes from perfusion maps. The basic idea of these is to train a model, using perfusion maps acquired at baseline and their corresponding follow-up images acquired several days after treatment, to automatically estimate the final lesion location and volume in new patients. Nevertheless, model training based on the original 4D CTP scans might be desirable, as they could contain more valuable information not directly represented in perfusion maps. Therefore, we aimed to develop and evaluate a temporal convolutional neural network (TCN) to predict stroke lesion outcomes directly from 4D CTP datasets acquired at admission, without computing any perfusion maps. Using a total of 176 CTP scans, we investigated the impact of the time window size by training the proposed TCN on various numbers of CTP frames: 8, 16, and 32 time points. For comparison purposes, we also trained a convolutional neural network based on perfusion maps. The results show that the model trained on 32 time points yielded significantly higher Dice values (0.33$\pm$0.21) than the models trained on 8 time points (0.25$\pm$0.20; P$<$0.05), 16 time points (0.28$\pm$0.21; P$<$0.001), and perfusion maps (0.23$\pm$0.18; P$<$0.05). These experiments demonstrate that the proposed model effectively extracts spatio-temporal data from CTP scans to predict stroke lesion outcomes, which leads to better results than using perfusion maps.} }
Endnote
%0 Conference Paper %T Stroke Lesion Outcome Prediction Based on 4D CT Perfusion Data Using Temporal Convolutional Networks %A Kimberly Amador %A Matthias Wilms %A Anthony Winder %A Jens Fiehler %A Nils Forkert %B Proceedings of the Fourth Conference on Medical Imaging with Deep Learning %C Proceedings of Machine Learning Research %D 2021 %E Mattias Heinrich %E Qi Dou %E Marleen de Bruijne %E Jan Lellmann %E Alexander Schläfer %E Floris Ernst %F pmlr-v143-amador21a %I PMLR %P 22--33 %U https://proceedings.mlr.press/v143/amador21a.html %V 143 %X Acute ischemic stroke is caused by a blockage in the cerebral arteries, resulting in long-term disability and sometimes death. To determine the optimal treatment strategy, a patient-specific assessment is often based on advanced neuroimaging data, such as spatio-temporal (4D) CT Perfusion (CTP) imaging. To date, perfusion maps are typically calculated from 4D CTP data and then thresholded to localize and quantify the stroke lesion core and tissue-at-risk. A few studies have recently developed deep learning methods to predict stroke lesion outcomes from perfusion maps. The basic idea of these is to train a model, using perfusion maps acquired at baseline and their corresponding follow-up images acquired several days after treatment, to automatically estimate the final lesion location and volume in new patients. Nevertheless, model training based on the original 4D CTP scans might be desirable, as they could contain more valuable information not directly represented in perfusion maps. Therefore, we aimed to develop and evaluate a temporal convolutional neural network (TCN) to predict stroke lesion outcomes directly from 4D CTP datasets acquired at admission, without computing any perfusion maps. Using a total of 176 CTP scans, we investigated the impact of the time window size by training the proposed TCN on various numbers of CTP frames: 8, 16, and 32 time points. For comparison purposes, we also trained a convolutional neural network based on perfusion maps. The results show that the model trained on 32 time points yielded significantly higher Dice values (0.33$\pm$0.21) than the models trained on 8 time points (0.25$\pm$0.20; P$<$0.05), 16 time points (0.28$\pm$0.21; P$<$0.001), and perfusion maps (0.23$\pm$0.18; P$<$0.05). These experiments demonstrate that the proposed model effectively extracts spatio-temporal data from CTP scans to predict stroke lesion outcomes, which leads to better results than using perfusion maps.
APA
Amador, K., Wilms, M., Winder, A., Fiehler, J. & Forkert, N.. (2021). Stroke Lesion Outcome Prediction Based on 4D CT Perfusion Data Using Temporal Convolutional Networks. Proceedings of the Fourth Conference on Medical Imaging with Deep Learning, in Proceedings of Machine Learning Research 143:22-33 Available from https://proceedings.mlr.press/v143/amador21a.html.

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