Multi-Label Generalized Zero Shot Learning for the Classification of Disease in Chest Radiographs

Nasir Hayat, Hazem Lashen, Farah E. Shamout
Proceedings of the 6th Machine Learning for Healthcare Conference, PMLR 149:461-477, 2021.

Abstract

Despite the success of deep neural networks in chest X-ray (CXR) diagnosis, supervised learning only allows the prediction of disease classes that were seen during training. At inference, these networks cannot predict an unseen disease class. Incorporating a new class requires the collection of labeled data, which is not a trivial task, especially for less frequently-occurring diseases. As a result, it becomes inconceivable to build a model that can diagnose all possible disease classes. Here, we propose a multi-label generalized zero shot learning (CXR-ML-GZSL) network that can simultaneously predict multiple seen and unseen diseases in CXR images. Given an input image, CXR-ML-GZSL learns a visual representation guided by the input’s corresponding semantics extracted from a rich medical text corpus. Towards this ambitious goal, we propose to map both visual and semantic modalities to a latent feature space using a novel learning objective. The objective ensures that (i) the most relevant labels for the query image are ranked higher than irrelevant labels, (ii) the network learns a visual representation that is aligned with its semantics in the latent feature space, and (iii) the mapped semantics preserve their original inter-class representation. The network is end-to-end trainable and requires no independent pre-training for the offline feature extractor. Experiments on the NIH Chest X-ray dataset show that our network outperforms two strong baselines in terms of recall, precision, f1 score, and area under the receiver operating characteristic curve. Our code is publicly available at: https://github.com/nyuad-cai/CXR-ML-GZSL.git

Cite this Paper

BibTeX
@InProceedings{pmlr-v149-hayat21a, title = {Multi-Label Generalized Zero Shot Learning for the Classification of Disease in Chest Radiographs}, author = {Hayat, Nasir and Lashen, Hazem and Shamout, Farah E.}, booktitle = {Proceedings of the 6th Machine Learning for Healthcare Conference}, pages = {461--477}, year = {2021}, editor = {Jung, Ken and Yeung, Serena and Sendak, Mark and Sjoding, Michael and Ranganath, Rajesh}, volume = {149}, series = {Proceedings of Machine Learning Research}, month = {06--07 Aug}, publisher = {PMLR}, pdf = {https://proceedings.mlr.press/v149/hayat21a/hayat21a.pdf}, url = {https://proceedings.mlr.press/v149/hayat21a.html}, abstract = {Despite the success of deep neural networks in chest X-ray (CXR) diagnosis, supervised learning only allows the prediction of disease classes that were seen during training. At inference, these networks cannot predict an unseen disease class. Incorporating a new class requires the collection of labeled data, which is not a trivial task, especially for less frequently-occurring diseases. As a result, it becomes inconceivable to build a model that can diagnose all possible disease classes. Here, we propose a multi-label generalized zero shot learning (CXR-ML-GZSL) network that can simultaneously predict multiple seen and unseen diseases in CXR images. Given an input image, CXR-ML-GZSL learns a visual representation guided by the input’s corresponding semantics extracted from a rich medical text corpus. Towards this ambitious goal, we propose to map both visual and semantic modalities to a latent feature space using a novel learning objective. The objective ensures that (i) the most relevant labels for the query image are ranked higher than irrelevant labels, (ii) the network learns a visual representation that is aligned with its semantics in the latent feature space, and (iii) the mapped semantics preserve their original inter-class representation. The network is end-to-end trainable and requires no independent pre-training for the offline feature extractor. Experiments on the NIH Chest X-ray dataset show that our network outperforms two strong baselines in terms of recall, precision, f1 score, and area under the receiver operating characteristic curve. Our code is publicly available at: https://github.com/nyuad-cai/CXR-ML-GZSL.git} }
Endnote
%0 Conference Paper %T Multi-Label Generalized Zero Shot Learning for the Classification of Disease in Chest Radiographs %A Nasir Hayat %A Hazem Lashen %A Farah E. Shamout %B Proceedings of the 6th Machine Learning for Healthcare Conference %C Proceedings of Machine Learning Research %D 2021 %E Ken Jung %E Serena Yeung %E Mark Sendak %E Michael Sjoding %E Rajesh Ranganath %F pmlr-v149-hayat21a %I PMLR %P 461--477 %U https://proceedings.mlr.press/v149/hayat21a.html %V 149 %X Despite the success of deep neural networks in chest X-ray (CXR) diagnosis, supervised learning only allows the prediction of disease classes that were seen during training. At inference, these networks cannot predict an unseen disease class. Incorporating a new class requires the collection of labeled data, which is not a trivial task, especially for less frequently-occurring diseases. As a result, it becomes inconceivable to build a model that can diagnose all possible disease classes. Here, we propose a multi-label generalized zero shot learning (CXR-ML-GZSL) network that can simultaneously predict multiple seen and unseen diseases in CXR images. Given an input image, CXR-ML-GZSL learns a visual representation guided by the input’s corresponding semantics extracted from a rich medical text corpus. Towards this ambitious goal, we propose to map both visual and semantic modalities to a latent feature space using a novel learning objective. The objective ensures that (i) the most relevant labels for the query image are ranked higher than irrelevant labels, (ii) the network learns a visual representation that is aligned with its semantics in the latent feature space, and (iii) the mapped semantics preserve their original inter-class representation. The network is end-to-end trainable and requires no independent pre-training for the offline feature extractor. Experiments on the NIH Chest X-ray dataset show that our network outperforms two strong baselines in terms of recall, precision, f1 score, and area under the receiver operating characteristic curve. Our code is publicly available at: https://github.com/nyuad-cai/CXR-ML-GZSL.git
APA
Hayat, N., Lashen, H. & Shamout, F.E.. (2021). Multi-Label Generalized Zero Shot Learning for the Classification of Disease in Chest Radiographs. Proceedings of the 6th Machine Learning for Healthcare Conference, in Proceedings of Machine Learning Research 149:461-477 Available from https://proceedings.mlr.press/v149/hayat21a.html.

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