Meta-Dependence in Conditional Independence Testing

Bijan Mazaheri, Jiaqi Zhang, Caroline Uhler
Proceedings of the 42nd Conference on Uncertainty in Artificial Intelligence, PMLR 337:4427-4440, 2026.

Abstract

Conditional independence testing is a critical component of feature screening, invariant statistical models, and causal discovery. Many of these algorithms rely on the sequential application of conditional independence tests, and their stability hinges on how their outcomes interact. We study this "meta-dependence" between conditional independence properties using the following geometric intuition: satisfying each conditional independence property constrains the space of possible joint distributions to a manifold. The "meta-dependence" of multiple conditional independences in a probability distribution is informed by its position relative to these manifolds. We provide a simple-to-compute measure of this meta-dependence using moment projections, with a closed-form expression for multivariate {Gaussian} distributions, and consolidate our findings empirically using both synthetic and real-world data. Our measure of meta-dependence does not rely on graphical properties of the distribution and can be computed directly from summary statistics such as a covariance matrix, allowing for various applications. We demonstrate one use case of meta-dependence, using a simple redundancy metric to tune significance thresholds and improve causal discovery.

Cite this Paper


BibTeX
@InProceedings{pmlr-v337-mazaheri26a, title = {Meta-Dependence in Conditional Independence Testing}, author = {Mazaheri, Bijan and Zhang, Jiaqi and Uhler, Caroline}, booktitle = {Proceedings of the 42nd Conference on Uncertainty in Artificial Intelligence}, pages = {4427--4440}, year = {2026}, editor = {Perković, Emilija and Malinsky, Daniel}, volume = {337}, series = {Proceedings of Machine Learning Research}, month = {17--21 Aug}, publisher = {PMLR}, pdf = {https://raw.githubusercontent.com/mlresearch/v337/main/assets/mazaheri26a/mazaheri26a.pdf}, url = {https://proceedings.mlr.press/v337/mazaheri26a.html}, abstract = {Conditional independence testing is a critical component of feature screening, invariant statistical models, and causal discovery. Many of these algorithms rely on the sequential application of conditional independence tests, and their stability hinges on how their outcomes interact. We study this "meta-dependence" between conditional independence properties using the following geometric intuition: satisfying each conditional independence property constrains the space of possible joint distributions to a manifold. The "meta-dependence" of multiple conditional independences in a probability distribution is informed by its position relative to these manifolds. We provide a simple-to-compute measure of this meta-dependence using moment projections, with a closed-form expression for multivariate {Gaussian} distributions, and consolidate our findings empirically using both synthetic and real-world data. Our measure of meta-dependence does not rely on graphical properties of the distribution and can be computed directly from summary statistics such as a covariance matrix, allowing for various applications. We demonstrate one use case of meta-dependence, using a simple redundancy metric to tune significance thresholds and improve causal discovery.} }
Endnote
%0 Conference Paper %T Meta-Dependence in Conditional Independence Testing %A Bijan Mazaheri %A Jiaqi Zhang %A Caroline Uhler %B Proceedings of the 42nd Conference on Uncertainty in Artificial Intelligence %C Proceedings of Machine Learning Research %D 2026 %E Emilija Perković %E Daniel Malinsky %F pmlr-v337-mazaheri26a %I PMLR %P 4427--4440 %U https://proceedings.mlr.press/v337/mazaheri26a.html %V 337 %X Conditional independence testing is a critical component of feature screening, invariant statistical models, and causal discovery. Many of these algorithms rely on the sequential application of conditional independence tests, and their stability hinges on how their outcomes interact. We study this "meta-dependence" between conditional independence properties using the following geometric intuition: satisfying each conditional independence property constrains the space of possible joint distributions to a manifold. The "meta-dependence" of multiple conditional independences in a probability distribution is informed by its position relative to these manifolds. We provide a simple-to-compute measure of this meta-dependence using moment projections, with a closed-form expression for multivariate {Gaussian} distributions, and consolidate our findings empirically using both synthetic and real-world data. Our measure of meta-dependence does not rely on graphical properties of the distribution and can be computed directly from summary statistics such as a covariance matrix, allowing for various applications. We demonstrate one use case of meta-dependence, using a simple redundancy metric to tune significance thresholds and improve causal discovery.
APA
Mazaheri, B., Zhang, J. & Uhler, C.. (2026). Meta-Dependence in Conditional Independence Testing. Proceedings of the 42nd Conference on Uncertainty in Artificial Intelligence, in Proceedings of Machine Learning Research 337:4427-4440 Available from https://proceedings.mlr.press/v337/mazaheri26a.html.

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