Learning Representations from Incomplete EHR Data with Dual-Masked Autoencoding

Xiao Xiang, David Restrepo, Hyewon Jeong, Yugang Jia, Leo Anthony Celi
Proceedings of the 11th Machine Learning for Healthcare Conference, PMLR 340:2175-2201, 2026.

Abstract

Electronic health records (EHR) arrive masked. Clinicians order measurements selectively, and any patient table thus contains only a subset of the values that characterize the underlying physiological state. Prior masked modeling approaches on EHR data either impute the table before learning, represent missingness through a dedicated placeholder signal, or optimize solely for imputation, which limits the representations they learn for downstream clinical tasks and carries every unobserved entry through the encoder. We introduce AID-MAE, an Augmented-Intrinsic Dual-Masked Autoencoder that learns directly from incomplete tables by combining the intrinsic mask the record already carries with an augmented mask that hides a subset of observed values for reconstruction during pretraining. Neither type of masked entry enters the encoder, so attention operates only over what was observed. AID-MAE achieves consistent improvements over strong baselines across multiple clinical tasks on two datasets. Across experiments, we discuss that recovering the missing entries is not a prerequisite for learning and show that the representations learned carry clinical structure without supervision.

Cite this Paper


BibTeX
@InProceedings{pmlr-v340-xiang26a, title = {Learning Representations from Incomplete EHR Data with Dual-Masked Autoencoding}, author = {Xiang, Xiao and Restrepo, David and Jeong, Hyewon and Jia, Yugang and Celi, Leo Anthony}, booktitle = {Proceedings of the 11th Machine Learning for Healthcare Conference}, pages = {2175--2201}, year = {2026}, editor = {Krishnan, Rahul G. and van Amsterdam, Wouter A. C. and Chopra, Sumit and Overgaard, Shauna and Hughes, Michael and Ötleş, Erkin and Shen, Yiqiu and Shanmugam, Divya and Nayan, Madhur and Engelhard, Matthew and Fackler, Jim and Oberst, Michael}, volume = {340}, series = {Proceedings of Machine Learning Research}, month = {12--14 Aug}, publisher = {PMLR}, pdf = {https://raw.githubusercontent.com/mlresearch/v340/main/assets/xiang26a/xiang26a.pdf}, url = {https://proceedings.mlr.press/v340/xiang26a.html}, abstract = {Electronic health records (EHR) arrive masked. Clinicians order measurements selectively, and any patient table thus contains only a subset of the values that characterize the underlying physiological state. Prior masked modeling approaches on EHR data either impute the table before learning, represent missingness through a dedicated placeholder signal, or optimize solely for imputation, which limits the representations they learn for downstream clinical tasks and carries every unobserved entry through the encoder. We introduce AID-MAE, an Augmented-Intrinsic Dual-Masked Autoencoder that learns directly from incomplete tables by combining the intrinsic mask the record already carries with an augmented mask that hides a subset of observed values for reconstruction during pretraining. Neither type of masked entry enters the encoder, so attention operates only over what was observed. AID-MAE achieves consistent improvements over strong baselines across multiple clinical tasks on two datasets. Across experiments, we discuss that recovering the missing entries is not a prerequisite for learning and show that the representations learned carry clinical structure without supervision.} }
Endnote
%0 Conference Paper %T Learning Representations from Incomplete EHR Data with Dual-Masked Autoencoding %A Xiao Xiang %A David Restrepo %A Hyewon Jeong %A Yugang Jia %A Leo Anthony Celi %B Proceedings of the 11th Machine Learning for Healthcare Conference %C Proceedings of Machine Learning Research %D 2026 %E Rahul G. Krishnan %E Wouter A. C. van Amsterdam %E Sumit Chopra %E Shauna Overgaard %E Michael Hughes %E Erkin Ötleş %E Yiqiu Shen %E Divya Shanmugam %E Madhur Nayan %E Matthew Engelhard %E Jim Fackler %E Michael Oberst %F pmlr-v340-xiang26a %I PMLR %P 2175--2201 %U https://proceedings.mlr.press/v340/xiang26a.html %V 340 %X Electronic health records (EHR) arrive masked. Clinicians order measurements selectively, and any patient table thus contains only a subset of the values that characterize the underlying physiological state. Prior masked modeling approaches on EHR data either impute the table before learning, represent missingness through a dedicated placeholder signal, or optimize solely for imputation, which limits the representations they learn for downstream clinical tasks and carries every unobserved entry through the encoder. We introduce AID-MAE, an Augmented-Intrinsic Dual-Masked Autoencoder that learns directly from incomplete tables by combining the intrinsic mask the record already carries with an augmented mask that hides a subset of observed values for reconstruction during pretraining. Neither type of masked entry enters the encoder, so attention operates only over what was observed. AID-MAE achieves consistent improvements over strong baselines across multiple clinical tasks on two datasets. Across experiments, we discuss that recovering the missing entries is not a prerequisite for learning and show that the representations learned carry clinical structure without supervision.
APA
Xiang, X., Restrepo, D., Jeong, H., Jia, Y. & Celi, L.A.. (2026). Learning Representations from Incomplete EHR Data with Dual-Masked Autoencoding. Proceedings of the 11th Machine Learning for Healthcare Conference, in Proceedings of Machine Learning Research 340:2175-2201 Available from https://proceedings.mlr.press/v340/xiang26a.html.

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