Contextual Constrained Learning for Dose-Finding Clinical Trials

Hyun-Suk Lee, Cong Shen, James Jordon, Mihaela Schaar
Proceedings of the Twenty Third International Conference on Artificial Intelligence and Statistics, PMLR 108:2645-2654, 2020.

Abstract

Clinical trials in the medical domain are constrained by budgets. The number of patients that can be recruited is therefore limited. When a patient population is heterogeneous, this creates difficulties in learning subgroup specific responses to a particular drug and especially for a variety of dosages. In addition, patient recruitment can be difficult by the fact that clinical trials do not aim to provide a benefit to any given patient in the trial. In this paper, we propose C3T-Budget, a contextual constrained clinical trial algorithm for dose-finding under both budget and safety constraints. The algorithm aims to maximize drug efficacy within the clinical trial while also learning about the drug being tested. C3T-Budget recruits patients with consideration of the remaining budget, the remaining time, and the characteristics of each group, such as the population distribution, estimated expected efficacy, and estimation credibility. In addition, the algorithm aims to avoid unsafe dosages. These characteristics are further illustrated in a simulated clinical trial study, which corroborates the theoretical analysis and demonstrates an efficient budget usage as well as a balanced learning-treatment trade-off.

Cite this Paper

BibTeX
@InProceedings{pmlr-v108-lee20a, title = {Contextual Constrained Learning for Dose-Finding Clinical Trials}, author = {Lee, Hyun-Suk and Shen, Cong and Jordon, James and van der Schaar, Mihaela}, booktitle = {Proceedings of the Twenty Third International Conference on Artificial Intelligence and Statistics}, pages = {2645--2654}, year = {2020}, editor = {Chiappa, Silvia and Calandra, Roberto}, volume = {108}, series = {Proceedings of Machine Learning Research}, month = {26--28 Aug}, publisher = {PMLR}, pdf = {http://proceedings.mlr.press/v108/lee20a/lee20a.pdf}, url = {https://proceedings.mlr.press/v108/lee20a.html}, abstract = {Clinical trials in the medical domain are constrained by budgets. The number of patients that can be recruited is therefore limited. When a patient population is heterogeneous, this creates difficulties in learning subgroup specific responses to a particular drug and especially for a variety of dosages. In addition, patient recruitment can be difficult by the fact that clinical trials do not aim to provide a benefit to any given patient in the trial. In this paper, we propose C3T-Budget, a contextual constrained clinical trial algorithm for dose-finding under both budget and safety constraints. The algorithm aims to maximize drug efficacy within the clinical trial while also learning about the drug being tested. C3T-Budget recruits patients with consideration of the remaining budget, the remaining time, and the characteristics of each group, such as the population distribution, estimated expected efficacy, and estimation credibility. In addition, the algorithm aims to avoid unsafe dosages. These characteristics are further illustrated in a simulated clinical trial study, which corroborates the theoretical analysis and demonstrates an efficient budget usage as well as a balanced learning-treatment trade-off.} }
Endnote
%0 Conference Paper %T Contextual Constrained Learning for Dose-Finding Clinical Trials %A Hyun-Suk Lee %A Cong Shen %A James Jordon %A Mihaela Schaar %B Proceedings of the Twenty Third International Conference on Artificial Intelligence and Statistics %C Proceedings of Machine Learning Research %D 2020 %E Silvia Chiappa %E Roberto Calandra %F pmlr-v108-lee20a %I PMLR %P 2645--2654 %U https://proceedings.mlr.press/v108/lee20a.html %V 108 %X Clinical trials in the medical domain are constrained by budgets. The number of patients that can be recruited is therefore limited. When a patient population is heterogeneous, this creates difficulties in learning subgroup specific responses to a particular drug and especially for a variety of dosages. In addition, patient recruitment can be difficult by the fact that clinical trials do not aim to provide a benefit to any given patient in the trial. In this paper, we propose C3T-Budget, a contextual constrained clinical trial algorithm for dose-finding under both budget and safety constraints. The algorithm aims to maximize drug efficacy within the clinical trial while also learning about the drug being tested. C3T-Budget recruits patients with consideration of the remaining budget, the remaining time, and the characteristics of each group, such as the population distribution, estimated expected efficacy, and estimation credibility. In addition, the algorithm aims to avoid unsafe dosages. These characteristics are further illustrated in a simulated clinical trial study, which corroborates the theoretical analysis and demonstrates an efficient budget usage as well as a balanced learning-treatment trade-off.
APA
Lee, H., Shen, C., Jordon, J. & Schaar, M.. (2020). Contextual Constrained Learning for Dose-Finding Clinical Trials. Proceedings of the Twenty Third International Conference on Artificial Intelligence and Statistics, in Proceedings of Machine Learning Research 108:2645-2654 Available from https://proceedings.mlr.press/v108/lee20a.html.

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