Matrix-normal models for fMRI analysis

Michael Shvartsman, Narayanan Sundaram, Mikio Aoi, Adam Charles, Theodore Willke, Jonathan Cohen
Proceedings of the Twenty-First International Conference on Artificial Intelligence and Statistics, PMLR 84:1914-1923, 2018.

Abstract

Multivariate analysis of fMRI data has bene- fited substantially from advances in machine learning. Most recently, a range of prob- abilistic latent variable models applied to fMRI data have been successful in a variety of tasks, including identifying similarity pat- terns in neural data, combining multi-subject datasets, and mapping between brain and be- havior. Although these methods share some underpinnings, they have been developed as distinct methods, with distinct algorithms and software tools. We show how the matrix- variate normal (MN) formalism can unify some of these methods into a single frame- work. In doing so, we gain the ability to reuse noise modeling assumptions, algorithms, and code across models. Our primary theoretical contribution shows how some of these meth- ods can be written as instantiations of the same model, allowing us to generalize them to flexibly modeling structured noise covari- ances. Our formalism permits novel model variants and improved estimation strategies for SRM and RSA using substantially fewer parameters. We empirically demonstrate ad- vantages of our two new methods: for MN-RSA, we show up to 10x improvement in run- time, up to 6x improvement in RMSE, and more conservative behavior under the null. For MN-SRM, our method grants a modest improvement to out-of-sample reconstruction while relaxing the orthonormality constraint of SRM. We also provide a software prototyp- ing tool for MN models that can flexibly reuse noise covariance assumptions and algorithms across models.

Cite this Paper

BibTeX
@InProceedings{pmlr-v84-shvartsman18a, title = {Matrix-normal models for fMRI analysis}, author = {Shvartsman, Michael and Sundaram, Narayanan and Aoi, Mikio and Charles, Adam and Willke, Theodore and Cohen, Jonathan}, booktitle = {Proceedings of the Twenty-First International Conference on Artificial Intelligence and Statistics}, pages = {1914--1923}, year = {2018}, editor = {Storkey, Amos and Perez-Cruz, Fernando}, volume = {84}, series = {Proceedings of Machine Learning Research}, month = {09--11 Apr}, publisher = {PMLR}, pdf = {http://proceedings.mlr.press/v84/shvartsman18a/shvartsman18a.pdf}, url = {https://proceedings.mlr.press/v84/shvartsman18a.html}, abstract = {Multivariate analysis of fMRI data has bene- fited substantially from advances in machine learning. Most recently, a range of prob- abilistic latent variable models applied to fMRI data have been successful in a variety of tasks, including identifying similarity pat- terns in neural data, combining multi-subject datasets, and mapping between brain and be- havior. Although these methods share some underpinnings, they have been developed as distinct methods, with distinct algorithms and software tools. We show how the matrix- variate normal (MN) formalism can unify some of these methods into a single frame- work. In doing so, we gain the ability to reuse noise modeling assumptions, algorithms, and code across models. Our primary theoretical contribution shows how some of these meth- ods can be written as instantiations of the same model, allowing us to generalize them to flexibly modeling structured noise covari- ances. Our formalism permits novel model variants and improved estimation strategies for SRM and RSA using substantially fewer parameters. We empirically demonstrate ad- vantages of our two new methods: for MN-RSA, we show up to 10x improvement in run- time, up to 6x improvement in RMSE, and more conservative behavior under the null. For MN-SRM, our method grants a modest improvement to out-of-sample reconstruction while relaxing the orthonormality constraint of SRM. We also provide a software prototyp- ing tool for MN models that can flexibly reuse noise covariance assumptions and algorithms across models.} }
Endnote
%0 Conference Paper %T Matrix-normal models for fMRI analysis %A Michael Shvartsman %A Narayanan Sundaram %A Mikio Aoi %A Adam Charles %A Theodore Willke %A Jonathan Cohen %B Proceedings of the Twenty-First International Conference on Artificial Intelligence and Statistics %C Proceedings of Machine Learning Research %D 2018 %E Amos Storkey %E Fernando Perez-Cruz %F pmlr-v84-shvartsman18a %I PMLR %P 1914--1923 %U https://proceedings.mlr.press/v84/shvartsman18a.html %V 84 %X Multivariate analysis of fMRI data has bene- fited substantially from advances in machine learning. Most recently, a range of prob- abilistic latent variable models applied to fMRI data have been successful in a variety of tasks, including identifying similarity pat- terns in neural data, combining multi-subject datasets, and mapping between brain and be- havior. Although these methods share some underpinnings, they have been developed as distinct methods, with distinct algorithms and software tools. We show how the matrix- variate normal (MN) formalism can unify some of these methods into a single frame- work. In doing so, we gain the ability to reuse noise modeling assumptions, algorithms, and code across models. Our primary theoretical contribution shows how some of these meth- ods can be written as instantiations of the same model, allowing us to generalize them to flexibly modeling structured noise covari- ances. Our formalism permits novel model variants and improved estimation strategies for SRM and RSA using substantially fewer parameters. We empirically demonstrate ad- vantages of our two new methods: for MN-RSA, we show up to 10x improvement in run- time, up to 6x improvement in RMSE, and more conservative behavior under the null. For MN-SRM, our method grants a modest improvement to out-of-sample reconstruction while relaxing the orthonormality constraint of SRM. We also provide a software prototyp- ing tool for MN models that can flexibly reuse noise covariance assumptions and algorithms across models.
APA
Shvartsman, M., Sundaram, N., Aoi, M., Charles, A., Willke, T. & Cohen, J.. (2018). Matrix-normal models for fMRI analysis. Proceedings of the Twenty-First International Conference on Artificial Intelligence and Statistics, in Proceedings of Machine Learning Research 84:1914-1923 Available from https://proceedings.mlr.press/v84/shvartsman18a.html.

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